Detection of Antibodies against Glycolipids
نویسندگان
چکیده
To investigate whether antecedent cytomegalovirus (CMV) infections in patients with Guillain-Barre syndrome are associated with the presence of specific antiganglioside antibodies, acute phase serum samples from 130 patients with Guillain-Barre syndrome and 200 controls were tested. Anti-GM2 IgM antibodies were found more often in patients with Guillain-Barre syndrome with CMV infection (22%) than in patients without the infection (2%) (P = 0.003). CMV infections may elicit anti-GM2 antibodies in susceptible patients, which may contribute to the pathogenesis of Guii1ain-Barre syndrome associated with CMV. (J7 Neurol Neurosurg Psychiatry 1997;62:641-643)
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